Manzardo made his MLB debut in 2024 with the Guardians and has since shown real power potential in the middle of a big‑league lineup. In 2025 he hit over 25 home runs, including multiple multi‑homer games and clutch long balls.

Off the field, Manzardo made headlines for something truly admirable — he left the team mid‑season to be with his mother when she underwent a heart transplant, showing a strong commitment to family during a tough personal moment.